Your problem isn´t that you should believe this or that, but how to disentangle from the desire for safety

If you as a Life Artist realizes - that is to say: if you are enough aware - that the process of the will to power forms you on the background of a belief - as an expression of the desire for inner safety - then your problem isn´t that you should believe this or that, but that you should disentangle yourself from the desire for safety.

Can the mind then disentangle from the wish for safety?

This is the problem, and not what you should believe, or how much you should believe. That would only be an expression of the urge for philosophical safety; that is: being convinced about something, when you don´t have any philosophical life-teaching and practice, and everything else in world is uncertain.